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时间:2019-04-06 18:17  来源:网络整理  阅读次数: 复制分享 我要评论

我的研讨群的首要研讨仪式判定经过是器具分子。、遗传物质转移mouse的复数形式的生物情报学与电生理、不睦mouse的复数形式典型和原代培育的后根力量中心焦虑的细胞上研讨背根力量中心感触焦虑的细胞的功用和精神病领会不睦的分子机制,并对镇痛的举行屏风。。再者,由于帕金森的变得越来越大病人都患有慢性不睦。,我的把联套在车上企图剖析帕金森病的遗传物质调把持度。。

One of the main areas of research in my laboratory is to investigate the function of sensory neurons in dorsal root ganglia (DRG) and the 分子的 mechanism behind neuropathic pain on models of transgenic mouse and neuropathic pain surgery mouse, as well as primary DRG neuronal culture with technologies of 分子的 biology, bioinformatics and electrophysiology, and to screen pain 压器。 Additionally, my lab is also interested in deciphering the gene regulatory network for the coincidence of Parkinson’s disease and pain because most patients of Parkinson’s disease experience chronic pain.



任务和竞争经验:

迄今     特聘研讨员、硕士研讨生导师、博士研讨生导师,威尼斯人官网、转变医学晚期的研讨院。

  博士后研讨员,瑞典卡起伏的斯卡医学院医学生化与生物物理系。 

2008.2- 2012.5   博士,德国状况仪式与康健研讨中心/慕尼黑技术大学,生物。

   研讨助剂,中科院上海性命学科研讨院康健学科研讨所。

   硕士,中科院上海性命学科研讨院康健学科研讨所,分子生物与生物化学成份专业。

   奖学金获得者,山西大学,生物工艺学专业。

Education and Position:

Present  Principlal Investigator, Advanced institute of translational medicine, School of Medicine, Tongji 大学。

  Postdoctoral researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institute.

2008.2- 2012.5  Ph.D., Institute of Developmental Genetics, Helmholtz Zentrum Munich / Technical University Munich, Germany

  Research Assistant, Neurogenetics Lab, Shanghai institutes for Biological Sciences, Chinese Academy of Sciences.

   M.S., Shanghai institutes for Biological

Sciences, Chinese Academy of Sciences.

   B.S., Shanxi 大学。

本人近亲的研讨任务窗侧了miR-183家喻户晓的在开展中受到定额SHOX2脸色窗口把持两产仔型的机械指示性的的测量。,在成丁时零碎地调控精神病领会不睦遗传物质制度中间的核平安相处行列式制度和包孕镇痛药物Gabapentin的靶点CACNA2D1/2在内的80%的遗传物质,容纳精神病领会机械性不睦。;碰见精神病领会不睦的偶尔机制。,更确切地说,不变的不吃不睦传导率。TrkB正片低临界值机械接收器焦虑的细胞被使开始生效不睦科。不睦研讨专家Prof. Barde对本人的miR-183研讨了精神病领会不睦的把持。,宣布在Science同时间分类账。

中脑多巴胺的开采与遗物研讨进展:1)碰见miR-200家喻户晓的容纳SOX2E2F3容纳中脑焦虑的干细胞的产。miR-200家喻户晓的容纳Zeb2中脑多巴胺能焦虑的细胞在引起程序中卖的使发生;2)碰见GDNF-Pitx3-BDNF遗传物质调控道路助长多巴胺的引起和遗物;3)证明患有精神病焦虑的燃料行列式GDNF它对多巴胺能焦虑的细胞的潦倒有保卫功能。。

Our recent research work discovered that miR-183 cluster regulates the population sizes of two low threshold mechanoreceptors (LTMRs) through terminating the expression window of SHOX2 during dorsal root ganglion development and scales neuropathic pain in adult by regulating 80% genes in neuropathic pain gene network, 包孕 a core transcriptional factors network and CACNA2D1/2the targets of pain inhibitor Gabapentin; and that an unexpected mechanism behind neuropathic pain, which is that TrkB+ LTMRs, normally transmit pleasant tactile sensations, is recruited into nociceptive network under neuropathic 前提。 Prof. Barde, an expert in pain research field, wrote and published a “Perspective Review” about this work on the same issue of Science.

The contribution to the field of development and survival of midbrain dopaminergic neurons (mDA) includes that: 1) found that miR-200 family controls proliferation of midbrain stem cells through regulating SOX2 and E2F3 and miR-200 family regulating Zeb2 to affect the migration of mDA during developing; 2) uncovered that GDNF-Pitx3-BDNF gene regulatory pathway promotes the development and survival of midbrain dopaminergic neurons3demonstrated that Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron 退步。

Publications:

1. Sun L#, Liu Y# and Peng C. Different Manners of Interplay between MicroRNAs and Gene Programs in Neuronal 定额。 J Cell Signal 2018, 3:4. DOI: 10.4172/2576-1471.1000193.

2. Peng C1,§ Furlan A, Zhang M, Su J, Lübke M Lönnerberg P, Abdo H, Sontheimer J, Sundström E, Ernfors P2§. Termination of cell-type specification gene programs by miR-183 cluster determines the population sizes of low threshold 机械敏感的 焦虑的细胞。 Development. 2018145, dev165613. doi:10.1242/dev.165613 (§协同交流作者,1威尼斯人官网, 2卡JK罗琳斯卡医学院).

3. Zhang M, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, O, Watanabe M, M, Mitsios N, Mulder J, Harkany T*Hökfelt T*. Ca2+-binding protein NECAB2 facilitates inflammatory pain 超敏保守。 Journal Of Clinical Investigation. 2018 July 30. https://doi.org/10.1172/JCI120913.

4. Yang S, Toledo E, Rosmaninho P, Peng C, Uhlén P, Castro D, Arenas E. A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration. Communications Biology volume 1, Article number: 75 (2018). https://doi.org/10.1038/s42003-018-0080-0.

5. Peng C, Li L, Zhang M, Gonzales C, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J and Ernfors P. MiR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain 遗传物质。 学科。 2017 六月 16;356(6343):1168-1171. Science同时间分类账宣布了不睦研讨专家Prof. Barde本人的文字。Perspective review,被F1000劝告为杰出论文)

6. Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N. A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. J Neurosci. 2012 Sep 19;32(38):13292-308. (被F1000劝告为杰出论文)

7. Peng C, Aron L, Klein R, Li M, Wurst W, Prakash N, and Le W. Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic 焦虑的细胞。 J Neurosci.2011 Sep;31, 12802-12815.

8. Peng C*, Fan S*, Li X, Fan X, Ming M, Sun Z, Le W. Overexpression of pitx3 upregulates expression of BDNF and GDNF in SH-SY5Y cells and primary ventral mesencephalic 文明。FEBS 莱特。 2007 Apr 3;581(7):1357-61. Epub 2007 Mar 2.  协同在前 author

9. Li X, Peng C, Li L, Ming M, Yang D, Le W. Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 活化。J Gerontol A Biol Sci Med SCI。 2007 SEP;62(9):943-50。

10. Yang, D., Peng, C., Li, X., Fan, X., Li, L., Ming, M., Chen, S., and Le, W. Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell 线导出 neurotrophic factor and protect dopamine neurons in mesencephalon 文明。 J Neurosci Res.2008 Nov; 86(15), 3393-3400.

11.Li X, Yang D, Li L, Peng C, Chen S, Le W. Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic 文明。Neurochem Int. 2007 六月;50(7-8):959-65. Epub 2007 May 3.

Patent:

1.Pitx3遗传物质和发起人的器具,专利号:,想出者设计师:乐卫东,彭长庚


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